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Desktop versions (also called client-server applications) require a larger up-front payment but generally cost less over the long term than their hosted counterparts, which charge monthly or annual fees.
The 1933 Sanriku earthquake, a large normal-fault earthquake (Kanamori, 1971) also caused a large (up to 29 m) tsunami with about 3,000 casualties.
These combinations of detectors made it possible to perform accurate particle measurements over a large (up to 200 GV for protons) energy interval.
The values of k obtained in these studies exhibit a large, up to an order of magnitude, variability that is commonly attributed to the variations in the computational setups adopted in different studies.
"Le Bourget, which opens in mid-June, draws a large, up-market clientele to Paris," Donet says.
But residents in continuing-care communities generally make a large up-front payment that guarantees them the full spectrum of care for the duration of their lives.
We observed a large up-regulation of Chst5 during the differentiation of MSC.
During the late response, there is a large up-regulation of the defence-related genes LEA, metallothionein and PR-1.
Two of these genes, the putative LEA and epicotyl-specific tissue protein genes, showed a large up-regulation the last week of the experiment.
And, thirdly, you don't need to part with a large up-front investment.
Avoid organizations that charge a large up front fee.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com