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Post-marketing studies can detect adverse effects that occur rarely or because of extended intake, because administration occurs in a larger timeframe and study population than in the phase I-III clinical trials.
Of course, this neutrality is only valid in case of a single or a few selective events, but not necessarily in a larger timeframe where iterated selection might induce evolution (non-trivial neutrality will be discussed later).
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Although this could be extended to larger timeframes, we believe that it might not be fully reflective of the structure of high-frequency trading, where trading is very fast and timeframes are inherently small.
Although the RRM process can dynamically be adapted to small variations of the traffic load distribution through the PPA process, the outcome of CIAM is essential for the efficiency of the RRM operation under traffic load variations taking place in larger timeframes.
Workers move across the city within their workdays but also, as they pressed us to notice, over the larger timeframes of the city's histories and of their own work lives.
Embryo transfer was used in a large scale, short timeframe experiment to develop this herd for gene mapping.
The approach was largely opportunistic, iterative, drew on a range of sources, and was embedded in a larger evidence synthesis exercise carried out in a compressed timeframe.
Although there was a non-significant change in activity levels over this timeframe it is not known whether the choice of a smaller effect size (MCID < 4) and therefore a larger sample size requirement would have altered the observed results.
Compared with Twin A's timeframe, Twin B's timeframe will slow.
However, because public-private partnerships (PPPs) are planned during a long timeframe and involve a large number of groups, therefore, implementing greater levels of openness in disclosure is complicated.
Across the developmental timeframe, there is a large component of genetic variation among accessions for these traits.
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