Many expressed discomfort in prescribing the drug to such a large community without a large-scale outcomes study designed with these questions in mind.
Our results emphasize the need to evaluate these technologies - especially their impact on the process of care - before any large-scale outcome studies are attempted.
Our results emphasize the need to evaluate technologies used to measure stroke volume and cardiac output--especially their impact on the process of care--before any large-scale outcome studies are attempted.
To better characterize the nature and quantify the magnitude of the many impediments relevant to conducting a successful prospective study involving racial or ethnic minorities in HCT, we conducted a feasibility study to help guide planning of a larger scale outcome and disparity study in HCT.
However, this large-scale outcome masks regional variation and locations where accounting for unreported catch is essential for understanding trends in functional diversity.
By allowing an automated detection, quantification, and display of patient-ventilator asynchronies, the system introduced by Sinderby and colleagues [ 1] could provide the opportunity to conduct large-scale outcome studies on the impact of correcting patient-ventilator asynchrony.
Previous large-scale outcome trials in patients with impaired glucose tolerance have already demonstrated the need for screening large numbers of subjects to finally enroll the required number of participants.
Moreover, in two large-scale outcome studies evaluating the effects of atorvastatin 10 mg in these patients, there were only non-significant changes in HDL-C (1 2%) and TG (−4% to −19%) [ 156, 157].
Nevertheless, we believe that, despite the above limitations, the study may still provide useful insights for planning a large-scale patient outcome evaluation study.
Given the perceived historical problems of ACEi in this population and the large scale required for a clinical outcome trial, we planned an intermediate (physiological) study to determine whether there were any positive physiological changes, and an absence of harm, before embarking on a large-scale clinical outcome study.
While there are conflicting data on the role of H. pylori as a risk factor for UGICs with low-dose aspirin [ 69, 70], the ongoing large-scale outcomes study Helicobacter Eradication Aspirin Trial (HEAT; ClinicalTrials.gov identifier NCT01506986) promises to provide more definitive information on the relationship between H. pylori infection and GI bleeding during aspirin use.
