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The analytical virtue of this reform is that it provides an example of a large-scale introduction of competition; the main drawback is that the simultaneous nationwide implementation makes it difficult to establish counterfactuals.
The scientific uncertainty of the effectiveness of either policy, coupled with the practical problem of financing a large-scale introduction of the policies, was the opportunity that we recognized for putting a policy experiment in place.
8– 13 The use of test results after a large-scale introduction of RDTs may differ from those seen in smaller scale trials, as training and supervisory characteristics likely differ.
A limitation of any static companion model used to assess vaccine programs is the omission of indirect herd immunity effects that may be realized after a large-scale introduction of either rotavirus or HPV vaccination program [ 37, 64].
However, because the cost-effectiveness of a PCV program could be affected by potential serotype replacement or herd immunity effects that may be realized after a large-scale introduction, the importance of iterative evaluation as surveillance data become available cannot be overstated.
Initial effectiveness, estimated using two different methodologies was 80%95%5% CI-: 52.5 91.6%) for children 6 mo to less than 5 y of age and 73%95%5% CI-: 52 85%) for all ages.,,, However, since this was a large-scale introduction rather than a clinical placebo-controlled trial, interpretation of effectiveness was complicated by secular disease trends.
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That DT104 has not spread markedly in Australia and New Zealand may be explained both by geography and the very strict food and livestock import restrictions in force in these countries, which prevent any large-scale introduction and spread of foreign Salmonella types in the food animal production chain (34).
In this study we utilize a regional economic forest sector model, focusing on northern Sweden, in order to estimate the effect of a large scale introduction of stump harvest on the future use of forest fuel.
Because the cost-effectiveness of a PCV program could be affected by potential serotype replacement or herd immunity effects that may not be known until after a large scale introduction, type-specific surveillance and iterative evaluation will be critical.
Fourth, on a related note, it is crucial to monitor any trends in potential serotype replacement following large-scale introduction of a PCV into a local setting, since replacement disease would potentially diminish the long-term effectiveness of an immunization program.
A crucial step towards the large-scale introduction of plug-in hybrid electric vehicles (PHEVs) in the market is to reduce the cost of its battery systems.
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