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Such laws and protocols are drawn up in the hope of producing a large-scale effect, such as creating the blogosphere or facilitating scientific publishing.
Re "Save the Planet: Vote Smart," by Thomas L. Friedman (column, Oct. 21), argues that individual actions are largely irrelevant when it comes to problems such as global warming, but that a change in leaders can have a large-scale effect.
It has had a large-scale effect as far the as the sale of books, especially the backlist of books.
It also has the same five second limit, though it is unknown whether it can be used for a large-scale effect.
It can be used for a large-scale effect by placing a titanic gravity over a large area and blowing them; in this case it can be used to destroy an entire village - at the cost of shortening the user's lifespan and being unable to use it for several minutes.
Addition of higher levels of FIXa have a large-scale effect in aPTT, and have not been plotted so as to preserve the scale of the plot.
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In initial neighbourhood analyses using a bivariate form of the O-ring statistic with a homogeneous Poisson null model we found a significant large-scale effect, indicating that large palms are located in areas of somewhat lower sapling density (data not shown).
"There are examples like Ghana where you can see that if you can target the very poorest, you can achieve a very large-scale effect," says Britain's minister for international development, Stephen O'Brien.
Most importantly, the sum total output of this intensive intervention was only 4 implants per health facility per month, providing little confidence of a pathway to large-scale effect.
Early Birds and Worms Much discussion of global warming focuses, naturally, on its global effects -- rising sea levels or the large-scale effect on plants and animals.
"Iron Man 3" is a fitting leadoff hitter for the 2013 summer movie season: It's got flashy stars (Robert Downey Jr. and Gwyneth Paltrow reprise their "Iron Man" roles), large-scale effects, a third dimension and plenty of marking tie-ins.
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