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The phrase "a large void in" is correct and usable in written English.
It can be used to describe a significant absence or lack of something in a particular context, such as knowledge, resources, or emotional support.
Example: "The sudden departure of the team leader created a large void in the group's dynamics, leaving everyone feeling uncertain."
Alternatives: "a significant gap in" or "a considerable absence of".
Exact(13)
His passing leaves a large void in both the medical community and the community at large.
Mr Munro's family paid tribute to a "loving brother and a good friend and colleague" whose death would leave a "large void in a lot of people's lives".
PREISS--Fredric H. Our beloved brother, brother-in-law and uncle passed away after a long illness, leaving a large void in our lives.
He enjoyed life to the fullest and his passing will leave a large void in the hearts of the family members and friends whose lives he touched.
His departure creates a large void in the team's hierarchy, following the sudden resignation of Al Groh as head coach on Dec. 30.
Internet use is still growing, and so is the mobile Web, and Brazilians still face a large void in early-stage venture capital, presenting a major opportunity.
Similar(45)
The store that has everything apparently had a rather large void in its drugstore section, when women relied on it for the so-called "morning after" emergency contraception pill.
One example of a large void under the road surface was detected in this study, being clearly seen in the GPR data and then confirmed by drilling.
This was done so that any large voids in the concrete exposed during sand blasting would be filled, allowing for proper bonding between the epoxy adhesive and the concrete.
Several internal defects may deteriorate greatly this fruit: (a) creases and/or large voids in the flesh, (b) overripeness and (c) bruises due to impact.
Typical failures are large voids in the volume of the resulting metal lines.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com