The phrase "a large underestimation of" is correct and usable in written English.
It can be used when discussing a situation where the actual value or impact of something is significantly lower than what was previously assessed or predicted.
Example: "The report revealed a large underestimation of the project's costs, leading to budget overruns."
Alternatives: "a significant miscalculation of" or "a considerable undervaluation of".
However, those for the other lead isotopes have some problems and cause a large underestimation of the neutron flux from 0.5 to 5 MeV.
Because of the large amount of trapped charges, the measured effective mobility also leads to a large underestimation of the true band mobility and the potential of the material.
According to the observation, the water budget on the basin is significantly unbalanced; it is attributed to a large underestimation of precipitation, typical of high mountain areas.
This can lead to a large underestimation of the vent area in case of runaway reactions occurring when processes different from the ones considered for originally sizing the vent are carried out.
The results show the notable influence of the above non-standard contributions on both critical loads and deformation modes: if they are not included in the analysis as in simplified crack contact interface formulations, a large underestimation of the real failure load of the microcracked composite is obtained.
There was a large underestimation of EDV and ESV for all three cases.
Nonetheless, a possibly large underestimation of HEV spread in humans cannot be excluded because of asymptomatic cases, inadequate diagnostics, and scarce medical attention (21 ).
For patients with mGFR > 120 ml/min/1.73 m there was a very large underestimation of mGFR when eGFR values were derived from either the CKD-EPI equation: - 23.1 ± 22.8 ml/min/1.73 m (p < 0.001) or from the MDRD equation: -16.0 ± 28.8 ml/min/1.73 m (p < 0.05).
"I am at a loss to see how such a large underestimation, and the corresponding scale of what is required from the ICF, could not have been foreseen to a greater extent before now," he wrote.
However, the adiabatic approximation to time-dependent density functional theory, the most widespread ab initio model for electronically excited states, fails to accurately reproduce the absorption spectra of cyanine derivatives: it yields a systematic and large underestimation of the experimental wavelengths irrespective of the details of the computational protocol.
Parsimony misinference at multiple-up hit codons increases dramatically as a function of MCU (Figure 8E) and results in large underestimation of dup,pu (Figure 8F).
