The phrase "a large underestimation" is correct and usable in written English.
It can be used when discussing a situation where the actual value or impact is significantly greater than what was initially assessed or predicted.
Example: "The project's potential benefits were a large underestimation, as the final results exceeded all expectations."
Alternatives: "a significant miscalculation" or "a considerable undervaluation."
However, those for the other lead isotopes have some problems and cause a large underestimation of the neutron flux from 0.5 to 5 MeV.
Because of the large amount of trapped charges, the measured effective mobility also leads to a large underestimation of the true band mobility and the potential of the material.
According to the observation, the water budget on the basin is significantly unbalanced; it is attributed to a large underestimation of precipitation, typical of high mountain areas.
This can lead to a large underestimation of the vent area in case of runaway reactions occurring when processes different from the ones considered for originally sizing the vent are carried out.
The results show the notable influence of the above non-standard contributions on both critical loads and deformation modes: if they are not included in the analysis as in simplified crack contact interface formulations, a large underestimation of the real failure load of the microcracked composite is obtained.
There was a large underestimation of EDV and ESV for all three cases.
This leads to a larger underestimation or false-negative rate: 5 6 = 0.83 versus 0.36.
An alternative approach would be to estimate the buildup rate using identical time intervals in both regimes, but Monte Carlo simulations revealed that it would result in a larger underestimation in the high speed regime than using an approach that based the endpoint on a matched level of trial attrition (results not shown).
Nonetheless, a possibly large underestimation of HEV spread in humans cannot be excluded because of asymptomatic cases, inadequate diagnostics, and scarce medical attention (21 ).
For patients with mGFR > 120 ml/min/1.73 m there was a very large underestimation of mGFR when eGFR values were derived from either the CKD-EPI equation: - 23.1 ± 22.8 ml/min/1.73 m (p < 0.001) or from the MDRD equation: -16.0 ± 28.8 ml/min/1.73 m (p < 0.05).
However, the adiabatic approximation to time-dependent density functional theory, the most widespread ab initio model for electronically excited states, fails to accurately reproduce the absorption spectra of cyanine derivatives: it yields a systematic and large underestimation of the experimental wavelengths irrespective of the details of the computational protocol.
