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Variations in the NAA/creatine ratio over time have not been studied in a large TBI patient population.
The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial.
The present study gives a real-life example of the benefit two approaches to ordinal outcome analysis in a large TBI trial (the CRASH trial).
Many large studies of TBI prognosis have been conducted using The Traumatic Brain Injury Model Systems, which is a large TBI rehabilitation database nested in a multidisciplinary system of high-quality rehabilitation centers in the United States.
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8 Additionally, it has been acknowledged that the effectiveness of TBI care and rehabilitation on the prognosis in TBI are best explored in large TBI populations.
A large percentage of TBI victims show signs of further deterioration following the event (Sauaia et al. 1995).
This may be explained at least in part by the accumulation of apoptotic cells in the hair bulbs following the larger TBI doses (Fig. 3C).
The Eurotherm3235Trial will recruit 1,800 patients in 41 months and will be one of the largest TBI studies to date.
Aries et al. have found in their much larger TBI cohort that hypoperfusion was associated with mortality while hyperperfusion was correlated with severe disability.
A recent study by Feigin, 32 a large epidemiological study of TBI in New Zealand, has contributed to filling the knowledge gap on TBI incidence and severity.
Mild TBI (mTBI) accounts for 80 85% of all TBIs and as such represents a large proportion of disability from TBI [13].
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