Using specialized tools such PheWAS-View to investigate results on a larger summary level as well as the individual result level is key for interpretation, analysis, and sharing of PheWAS results.
It can be virtually impossible to ensure that a particular piece of data is removed entirely, especially if the data has been incorporated into a larger data summary where individual contributions can no longer be isolated.
While it is well recognized that the above discussed biases, as well as individual study quality, may have a large impact on summary odds ratios in meta analyses [6], these flaws are less likely to bias trends in odds ratios rather than summary odds ratios themselves.
The first plan presents, to a large extent, a summary of what the individual parts are doing.
If a large number of summary statistics are chosen, these may extract most of the information and thus limit the sampling variance.
In general, larger summary estimates for mortality were found in Europe and Asia (as WHO regions Europe A, Western Pacific region and multiregion in table 2 and online supplementary table S1).
These studies provide the largest summary to date for the spectrum of neurological manifestations that can occur in association with HPRT deficiency.
When moderate risk individuals were excluded from analyses, assessment tools for violence risk produced considerably larger summary diagnostic odds ratios (16.8, 10.8 to 26.3) and specificities (0.72, 0.63 to 0.80).
In summary, a large proportion of migraine patients did not treat their headache within the first hour of headache onset.
In summary, a large part of the genome is devoted to encode trans-sialidase and trans-sialidase-like proteins likely to be involved in the protection against a neutralizing activity that might prevent parasite development in the mammalian host.
