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The phrase "a large slice of" is correct and usable in written English.
It can be used to refer to a significant portion or amount of something, often in a figurative sense.
Example: "The project requires a large slice of our budget to ensure its success."
Alternatives: "a significant portion of" or "a big chunk of".
Exact(54)
That's a large slice of working Britain.
Clearly, a large slice of corporate America agrees with him.
Portraiture accounts for a large slice of material.
PayPal already pockets a large slice of online payments.
A large slice of global trade is counted in dollars.
Foreigners hold a large slice of American mortgage-backed securities.
Similar(5)
Burning fossil fuels to provide heat and hot water in buildings accounts for a large slice of current emissions.
Why does such a large slice of America admire him?
That's where the manager and a large slice of his squad currently find their Stoke careers.
That includes a large slice of American Catholics and members of other religions that oppose birth control.
Comac sees its C919 as grabbing a large slice of orders from domestic airlines.
More suggestions(25)
a larger slice of
a large slice of the electorate
an increasingly large slice of
a premium slice of
a large slice of the population
a large slice of land
a large slice of this
capture a large slice of
deferral of a large
a large interval of
a large ring of
a large bite of
a considerable slice of
a large bit of
a major slice of
a large proportion of
a large share of
a massive slice of
a broad slice of
a large cut of
a vast slice of
a large tranche of
a large fraction of
a large stretch of
a wide slice of
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com