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The phrase "a large shift of" is correct and usable in written English.
It can be used to describe a significant change or transition in various contexts, such as economics, social dynamics, or personal circumstances.
Example: "The recent economic policies have led to a large shift of wealth from the middle class to the upper class."
Alternatives: "a significant change in" or "a major transition of".
Exact(21)
It was found that a small difference in the χ values leads to a large shift of spinodal curve.
Notably, in the absence of internal Ca2+, the γ1 subunit promotes a large shift of the BK conductance-voltage curve to more negative potentials.
With an increase of illumination intensity (from 0 to 0.6 mW cm−2), a large shift of the threshold voltage (Vth) was observed (Supplementary Fig. 8) with the mobility increased to 12 cm2 V−1 Supplementaryntary Fig. 9).
The 60Co photons (with doses up to 2.9 kGy) show the presence of generation currents in the SiO2 Si interface, a large shift of the flatband voltage and a decrease of the hole mobility.
Potentiodynamic polarization studies in 3.5% NaCl solution revealed a large shift of ∼ 300 mV of the corrosion potential below the pitting potential for the 7075-T6 alloy, which correlated with the development of a finely-textured, uniform coating.
For a stoichiometric ratio of 5.56 mol% THF, we found a large shift of dissociation boundary to lower pressures and higher temperatures from the dissociation conditions of pure CO2 hydrate.
Similar(39)
Furthermore, a higher Co content leads to a larger shift of binding energy.
The turn to governance by dashboard in HE exemplifies a larger shift of governance in relation to big data.
We created the mutation table design to cause a larger shift of flight distance by a single mutation than in the original protocol.
This systematic scattering is due to a larger shift of the southern hemisphere focus northwards during the northern summer solstice and southwards during the southern summer solstice.
The specifically functionalised biotin sensors showed a frequency decrease of ~270 Hz (i.e. ~1.29 ng), a larger shift of 40 Hz (180 pg) than the in-situ reference levers that shifted only by ~230 Hz (~1.11 ng) in the 10th vibrational mode.
More suggestions(16)
a large change of
a large reorientation of
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a large downshift of
a broad shift of
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a large transformation of
a considerable shift of
a large scale shift of
a broader shift of
a large glass of
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com