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Although the Needleman-Wunsch algorithm is effective, it is too slow for probing a large sequence database.
"It's going to be a large sequence of events," said Mr Radhakrishnan.
Another contribution of our paper is a ground truth of a large sequence of images available in the Internet.
The per-pixel non-uniformity, a i, can be estimated using a flat field image computed as the average over a large sequence of non-saturated images.
The non-redundant and representative profiles obtained from this procedure, termed evolutionary profiles, are shown in initial results to outperform well-tested profiles in homology detection searches over a large sequence database.
A neighbor-joining tree analysis of the PCR-amplified laccase sequences showed a clear species-specificity, but also revealed that most fungal taxa possess several laccase genes showing a large sequence divergence.
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There is a large sequencing group with a battery of sequencers, a microarray group, a proteomics group, and several groups being formed.
The extent of transient, premature structure appears to correlate with the number of isoleucine, leucine, and valine (ILV) side chains that form a large sequence-local cluster involving the central β-sheet and helices α2, α3, and α4.
Three years ago, a large sequencing project found that such DNA repair gene defects are common in advanced prostate tumors.
"It strikes me that this is a cream-skimming approach," says Robert Waterston, head of a large sequencing project at Washington University in St . Louis
To dissect the genetic architecture of sporadic ALS, we undertook a large sequencing study in 755 apparently sporadic ALS cases and 959 controls, analyzing 10 ALS genes: SOD1, C9orf72, TARDBP, FUS, ANG, CHMP2B, ATXN2, NIPA1, SMN1, and UNC13A.
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