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"Though relatively small, with few cases of dementia, it should act as another incentive to start a large scale trial with homocysteine-lowering therapy using B vitamins to see whether such a simple treatment may slow the development of Alzheimer's or other dementia".
For a large scale trial it is important for an intervention to be reproducible.
However, it is unclear whether such a large scale trial can be completed with the inherent biases of both patients and surgeons in favor of new technology.
Dr Antonelli announced his intention to start a large scale trial to investigate the use of NIV in patients with hypoxaemic ARF.
These preliminary data indicate that the impact of the THP-V should be tested in its complete form in a large scale trial.
A large scale trial (RESPOND CRT, Clinicaltrial.gov: NCT01534234) has started and is planned to include up to 1000 patients to further investigate this rapidly evolving technology.
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A large-scale trial across a whole catchment is urgently needed, the MPs said.
But many clinicians caution that too much has been made of the new therapy before it's proven; a large-scale trial is now under way.
In September they will begin work on a large-scale trial to see whether FRET can accurately "hindcast" the clinical outcomes associated with 2,000 breast-cancer biopsies.
They are beginning a large-scale trial to see whether FRET can accurately "hindcast" the clinical outcomes associated with 2,000 breast-cancer biopsies.
It called for "safe injecting houses" for addicts to be set up together with a large-scale trial of heroin prescribing.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com