William Worrall Mayo (b. May 31 , 1819 near Manchester, Eng. d. March 6, 1911, Rochester, Minn., U.S). was the father of the doctors Mayo who developed a large-scale practice of medicine.
To carry out a large-scale practice-based open-label trial to evaluate the safety and efficacy of an angiotensin receptor blocker (ARB) in controlling blood pressure (BP) in the community setting, 703 practitioners recruited 2705 hypertensive patients.
From a practical perspective, however, the on the ground large scale practice of global health within this new paradigm poses some significant challenges.
An attractive feature of the photocatalytic conversion of CO2 to CH4 is that if successful on a large scale, the practice of blending H2 with natural gas which involves careful control of the relative amounts of H2 and natural gas can be replaced by the much safer and utilitarian blending of sunlight-derived CH4 with the natural gas grid.
During the development of the training course, we realised that it was impossible to implement our original idea to evaluate the training course on a large scale in practice in a randomised controlled trial (RCT), with as primary outcomes the claimants' acceptance of the physician's conclusions and satisfaction with the communication.
Such a joint venture took place in embryonic form recently when several countries participated in a large-scale exercise, "Barents Rescue 2009," that practiced an effective response to a number of emergency situations, ranging from fire-fighting to the release of radioactive nuclear waste, on both land and sea.
It's not activism on a large scale like I practiced in the past, but in helping find raffle prizes, recruiting jury members, watching hours of film footage and engaging in any number of small, seemingly insignificant acts I've found myself doing for the festival, I'm happy to be back in the activism community, even if it just means punching its tickets.
Growing preclinical and clinical evidence about blastocyst biopsy accuracy, safety and effectiveness indicate trophectoderm analysis as the most advantageous stage for all applications of preimplantation genetics although it was only recently introduced on a large scale into the clinical practice of IVF (Yang et al, 2012; Chang et al., 2013; Forman et al., 2013a, b; Scott et al., 2013a, b).
We observed drug utilization and prescription patterns through a large scale survey of clinical practices, which served as an effective tool for investigating the clinical pharmacology of these compounds.
Finally, although a large scale study, these general practices are drawn from one region of England, and while this might limit generalisability, the internal validity of the findings still remains.
The study used data routinely recorded in general practitioner (GP) electronic medical records making it possible to examine actual practice on a large scale, and the data used came from practices participating in a national morbidity data set which had all received training and financial support to maintain particularly high quality data.
