The phrase "a large scale manner" is correct and usable in written English.
It can be used to describe an approach or method that is extensive or significant in scope.
Example: "The project was executed in a large scale manner, involving multiple teams and resources."
Alternatives: "on a grand scale" or "in an extensive way".
These inconsistencies cause troubles for researchers wishing to refer to pathway information in a large-scale manner across different databases.
Phosphoproteomics offer us the possibility of investigating in a large-scale manner the functional role of proteins, which is a subject mostly neglected in large-scale proteome studies.
Ironically, as animal studies are not predictive for humans, the first clinical trials of a new drug in humans are themselves the most risky form of human-based research being performed in a large-scale manner today.
The conversion of biomass to fuels and chemicals faces substantial challenges if it is to be done on a large scale, in a sustainable manner, and at reasonable cost.
Currently FSEP does not have the infrastructure in place to administer the tests online on a large scale in a secure manner that would safe-guard the question bank.
It has not been possible to carry out such studies on a large scale in a robust manner, however, because genome-wide data sets like the International Haplotype Map Project (HapMap) (6, 7) are strongly affected by ascertainment bias: non-randomness in the polymorphisms chosen for analysis (8).
A Chinese artist who trained in Paris after World War II, Wu then turned to using ancient techniques of brush and ink on a large scale and in a contemporary manner.
Internet or web-based interventions (e-health) may be ideally suited for this purpose since they have been shown to deliver efficacious psychological intervention programs for depression [ 19] on a large scale in a cost effective manner.
This is indicative of a broader problem that is particularly acute in low and middle income countries, where life-saving and cost-effective technologies are becoming more readily accessible while the infrastructure and financial resources are not yet available to provide these on a large scale and in an equitable manner.
