This approach is able to simultaneously analyse a broad range of polar and nonpolar metabolites, which is ideal for a large-scale hypothesis-generating study with twofold faster data acquisition and analysis time when compared to the conventional methods.
Therefore our objective was to identify genetic variants involved in CWP by means of a large-scale hypothesis-free genome-wide association study (GWAS) meta-analysis including 2788 cases and 13 780 controls.
The large scale hypothesis generation tools presented here provide leads to new pathways, unexpected functions, and regulatory networks for many P450s in plant metabolism.
It is also extremely useful for generating and testing large scale hypotheses (e.g. latitudinal and cross-basin comparison) and planning shipboard surveys.
Another challenge of attempting a large scale evaluation of our hypothesis would be the high-throughput determination of the FAE activity.
Now a team of sociologists at Columbia University led by Duncan Watts, an assistant professor of sociology and author of "Small Worlds: The Dynamics of Networks Between Order and Randomness," is trying to assess the six-degrees hypothesis on a large scale, using e-mail as the medium for building the chains.
Until recently, it has not been possible to correlate duplication events directly with environment within a population on a large scale, making the testing of this hypothesis difficult.
Further clinical survey on a large scale should be added to confirm the hypothesis.
A global phylogeographical framework is critical to unravel the answers on large scale-hypotheses on the origins and evolution of R. solani AG-3 as a pathogen of domesticated crops within the Solanaceae.
Overall, the current study overcomes these caveats by using a large scale representative sample (NCS-R) to examine two hypotheses.
But this hypothesis hasn't been tested at a large scale, and new protocols would likely have their own security problems.
