The phrase "a large scale effect on" is correct and usable in written English.
It can be used when discussing the significant impact or influence that something has on a particular subject or area.
Example: "The new policy is expected to have a large scale effect on the economy, influencing job creation and investment."
Alternatives: "a significant impact on" or "a major influence on".
As the problem stands now, there is no compelling reason to believe that multiple targeting causes a large-scale effect on the correlation structure of Affymetrix gene expression data.
These modifications, many of which are initially at a microscale, are likely to have large scale effects on benthic seascapes.
Ultimately, our results could have larger scale effects on eco-evolutionary community dynamics.
Early Birds and Worms Much discussion of global warming focuses, naturally, on its global effects -- rising sea levels or the large-scale effect on plants and animals.
However, genomic analyses of communication signal senders has not kept apace with analyses of receivers, and it is not known whether sending a communication signal is associated with comparably large-scale effects on brain gene expression.
miRNAs are regulatory, non-coding RNAs about 21 23 nucleotides in length and are expressed at specific stages of tissue development or cell differentiation, and have large-scale effects on the expression of a variety of genes at the post-transcriptional level.
NAP1L5 has sequence similarity to NAP1, a cytoplasmic-nuclear shuttle protein for histones, that has large-scale effects on gene expression by chromatin restructuring [ 113].
Thus, predicted changes in precipitation patterns may affect the activity patterns of microbial populations, based on their life strategy, which could result in large-scale effects on soil biogeochemical processes, including soil C budgets and nutrient cycling.
Given the brain network dynamics, we hypothesized that SSRs have additional large-scale effects on the brain functional network that can be revealed by means of graph theory.
These vary from large-scale effects on soil structure and nutrient availability, to the enhancement of mycorrhizal infection or control of plant-parasitic nematodes.
We next investigated patterns of large-scale effects on the regulatory architecture that are attributable to founder and/or subspecies of origin.
