An accepted method of identifying large scale differences in gene expression is to use EST abundance as an indicator of transcript abundance.
This difference in synteny reflects the previously documented 4AL/5AL translocation [ 13, 26] and no other large scale differences in syntenic blocks were observed.
However, there are no data to suggest large scale differences in coding or patient case mix over time or between the two groups during the study period.
Most of the differentially expressed genes on the microarray were not related to sex function, suggesting large scale differences in gene expression between the sexes are present early in development.
To examine large scale differences in gene expression between life history stages, we used the more extensive dataset from A. palmata to compare large-scale patterns of gene expression in the four major life history stages that we sampled (egg, early planula stage, late planula stage, and adult).
The two crosses did not indicate any large-scale differences in genomic structure and had strikingly similar patterns of recombination across the genome, with similar regions of high and low recombination.
We hypothesized that, when examining the issue on a large scale, no difference in survival would exist between techniques.
Overall, we note large-scale differences in the regulation of regulons as determined by different sets of putative transcription factors in these species.
Even if it is true that only a few genes are relevant to the differences in behavior that we find, our results indicate, under the conditions studied, that the mechanism leading to the large-scale differences in gene expression is resulting in a previously unrecognized global level of change.
The connectivity profiles of these two regions do not show large-scale differences in the blind group (Supplementary Fig. 7B,C,E).
