The phrase "a large scale difference between" is correct and usable in written English.
It can be used when discussing significant variations or disparities between two or more entities, concepts, or measurements.
Example: "There is a large scale difference between the economic growth rates of developed and developing countries."
Alternatives: "a significant difference between" or "a major disparity between".
Hierarchical clustering and multidimensional scaling failed to uncover a large-scale difference between them.
Circular genome comparisons generated with BRIG [ 49] that show large scale differences between the P. aeruginosa genomes are included as Additional file 3: Data File 5, using PAO1 as the reference, and Additional file 4: Data File 6, using a PAHM4 pseudochromosome as the reference.
Freely dissolved and crayfish tissue PAH concentrations were standardized to total sample PAH concentration (ΣPAH) and 4th root transformed prior to PCA because preliminary tests indicated that this transformation improved overall data visualization and reduced the impact of large scaling differences between PAH proportions.
Comparisons of Btau4.6 and UMD3.1 to BtOM1.0 also revealed large-scale difference between these sequence assemblies.
Most of the differentially expressed genes on the microarray were not related to sex function, suggesting large scale differences in gene expression between the sexes are present early in development.
To examine large scale differences in gene expression between life history stages, we used the more extensive dataset from A. palmata to compare large-scale patterns of gene expression in the four major life history stages that we sampled (egg, early planula stage, late planula stage, and adult).
We corrected for differences in normal tissue contamination then calculated a Z score for the presence of large-scale differences between samples, as described in the Supplementary Methods file and Supplementary Figure 4. Seven pairs of tumours stood out as being significantly different (H08, H09, H10, H13, H14, H15 and H19; Supplementary Table 6).
Given the high habitat heterogeneity and environmental variability in these canyons and channels, we hypothesise that the nematode assemblages will be largely controlled by small-scale, local environmental conditions rather than large-scale differences between canyons or water depths.
Non-metric multidimensional scaling analysis reveals large-scale differences between the sister taxa S. frontalis and S. attenuata and the rest of the Delphininae.
