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We have developed a large-scale, constraint-based network model of the metabolic partnership between astrocytes and glutamatergic neurons that allows for a quantitative appraisal of the extent to which stoichiometry alone drives the energetics of the system.
Comparing with other optimization algorithms, simulations suggest that RNN has strong ability to search for exact solutions under the condition of large scale constraints.
Cost constraints prevented a large scale or full interrogation of the iron metabolism gene pathway.
The discretization of the ROC problem with PDE constraints leads to a large scale (non-convex) nonlinear semidefinite program (NSDP).
SDPARA can effectively solve SDPs with a large number of equality constraints; however, it does not solve SDPs with a large scale matrix variable with similar effectiveness.
The analysis was performed using the open-source software tool BioQuali and consisted of an automatic constraint-based analysis mimicking biologist's local reasoning on a large scale.
He does this on a large scale.
That's a large scale indeed.
This detailed map of constraint suggests that mammalian genomes co-opt fragments of mobile elements to act as gene regulatory sequence on a large scale.
This results in the use of a large scaling factor c in (10) to fulfill the power constraint (11).
My research area is Artificial Intelligence with a focus on large-scale constraint-based reasoning, optimization, and machine learning.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com