The merchandising of cigarettes on a large scale became practical with the development, around the time of the First World War, of a slightly acid cigarette tobacco, which allowed smokers to inhale without an immediate unpleasant effect.
The money to buy the drug on a large scale became available with the creation of the Global Fund to Fight AIDS, Tuberculosis and Malaria in 2002 and the Bush administration's introduction of the President's Malaria Initiative in 2005.
With wind generation technology maturing and the cost decreasing close to grid parity, grid integration of wind on a large scale became a principal barrier for further deployment and has been receiving intensive attention across academia, industry, and government sectors.
In 1993 when the difficulties of entering the export market profitably on a large scale became apparent, Mackay Sugar/ED&F Man and CSR applied to merge their operations, which would have resulted in a significant reduction of CSRs older refining capacity and a rationalisation of the market.
As these sets become larger (sometimes many thousands of sequences) and their members more divergent, their fast exploration on a large-scale becomes less feasible using traditional approaches such as alignments and trees.
Benefiting from current applications of high-throughput technologies, e.g. microarray and next-generation sequencing (NGS), simultaneously monitoring gene differential expressions in large scale becomes easier.
Moreover these effluents causes water pollution in large scale become serious environmental issue in recent years (Mahlambi et al. 2015).
Practised on a large scale, this becomes a crime against humanity recognised by the international criminal court.
As new sequencing technologies have become available, the ability to identify SINE insertions on a large scale has become feasible.
For many products, there are advantages in producing on a large scale; costs become lower as more is produced.
