The phrase "a large protective effect" is correct and usable in written English.
It can be used in contexts discussing the impact of a treatment, intervention, or factor that provides significant protection against a negative outcome.
Example: "The study found that the vaccine had a large protective effect against the virus, significantly reducing the risk of severe illness."
Alternatives: "a significant protective effect" or "a substantial protective effect".
However, the wide confidence intervals were consistent with a large protective effect, no effect, or a large adverse effect.
Furthermore a large protective effect of maternal education (beyond elementary level) was found in a Mexican population (OR 0.6 (95% CI 0.5; 0,8)) [ 44].
The estimate for regular care of dogs was slightly more precise, with a 95%CI indicating the data are compatible with effect estimates ranging from a large protective effect to a small detrimental effect.
Two studies in Mexican [30] and Indian [31] populations assessed associations with LUTS or surgery for LUTS, reporting a large protective effect of the insertion (pooled OR: 0.66; 95% CI, 0.49 0.90) but with high heterogeneity (I = 91.9%) (Fig. 3).
The primary Korean study had suggested a large protective effect of the minor allele, and the heterogeneity between studies might instead be explained by differences in populations, or a simple Proteus effect.
Medicaid was found to have a large protective effect; VLBW births would increase by approximately 14.5% if black mothers were not on Medicaid compared to mothers who were on Medicaid.
Consequently, we might then have seen a larger protective effect of aspirin, as the incompletion was higher among users of aspirin.
It is known that chemoprophylaxis against tuberculosis disease has a larger protective effect in HIV-infected individuals who are TST positive than it does in HIV-infected individuals who are TST negative (27).
The stratification of these studies, for example, has revealed that citrus fruit consumption was associated with a larger protective effect against oral cancer than overall fruit consumption, and was greater than green- or overall vegetable consumption [ 6].
Thus, meta-analyses of alcohol consumption and the risk of ischemic heart disease (Roerecke and Rehm 2012) and ischemic stroke (Taylor et al. 2009) found a larger protective effect for morbidity than for mortality related to these conditions.
Nevertheless, the trial does suggest a potentially large protective effect that was consistent throughout the follow-up period, and robust in sensitivity analysis.
