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The phrase "a large proportion of this" is correct and usable in written English.
It can be used when discussing a significant part or percentage of a particular subject or item being referenced.
Example: "In the survey results, a large proportion of this demographic expressed a preference for online shopping."
Alternatives: "a significant portion of this" or "a considerable amount of this".
Exact(60)
Following from neutral theory, divergence in gene expression patterns is expected to be proportional to taxonomic divergence between groups [59], and a large proportion of this variation must be due to genetic drift [67].
A large proportion of this hate speech has been directed towards the Rohingya, the Muslim minority in Myanmar.
Overdose from prescription opioids constitutes a large proportion of this burden.
Submarine power cables account for a large proportion of this cost.
A large proportion of this healthcare expenditure is attributable to the use of expensive urgent healthcare.
Still, a large proportion of this generation of Afghan girls is attending schools like this one, despite arson and gas attacks.
The native bee fauna provides an important ecosystem function, but a large proportion of this fauna in Europe is threatened as a result of habitat loss and fragmentation.
BAME and young people will make up a large proportion of this figure, and Ed Miliband is rightly addressing the issue with a drive to register a million missing voters.
By any reckoning of the number he killed -- Iraqi human rights groups' estimates begin at 300,000 -- a large proportion of this nation of 25 million were directly affected, and many more admit that they carry the trauma's scars.
This result indicates that EC was formed as an intermediate in the base-catalyzed reaction of PC with EG. However, a large proportion of this EC formed from PC was lost by decarboxylation.
A large proportion of this new Sinn Féin electorate will spend the Halloween weekend either behind closed doors in their semi-d's or travelling up to Donegal to holiday homes, hotels and B&Bs.
More suggestions(15)
a large slice of this
a large fraction of this
a large scale of this
a large degree of this
a large share of this
a large amount of this
a major proportion of this
a large part of this
a large distribution of this
a large percentage of this
a large dollop of this
a large component of this
a substantial proportion of this
a large volume of this
a tiny proportion of this
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com