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The phrase "a large problem in" is correct and usable in written English.
You can use it when discussing significant issues or challenges within a specific context or field.
Example: "There is a large problem in the healthcare system that needs immediate attention."
Alternatives: "a significant issue in" or "a major challenge in".
Exact(17)
These events speak to a large problem in China, where access to education is restricted for millions of children.
Cases of high-sided vehicles striking low bridges is a large problem in many countries, especially the UK.
The loss of the differentiated phenotype (dedifferentiation) during the expansion culture of donor chondrocytes remains a large problem in cartilage tissue engineering.
"We've seen an attack on innocent people in order to stimulate the ethno-sectarian violence that was really a large problem in this country in the last couple of years," the chief American military spokesman, Brig.
Joseph Ciolino, an ophthalmologist at the Massachusetts Eye and Ear Infirmary and Harvard Medical School, says the need for such a device is great: "Cataracts are the leading cause of blindness worldwide and a large problem in the developing world.
However, the VIFs for our models are low, with an average VIF being around 2. As such, multicollinearity is not a large problem in the models.
Similar(43)
And fuel is relatively a larger problem in California.
Q. Can a mistake be a sign of a larger problem in your organization?
I feel this will become a larger problem in the future in many different businesses.
"The big picture means asking if this is a symbol of a larger problem in Israel.
The recent study may also signal a larger problem in insurance benefit design.
More suggestions(16)
a considerable problem in
a huge problem in
a significant problem in
a vast problem in
a massive problem in
a sizeable problem in
a substantial problem in
a broad problem in
a tremendous problem in
a large scale problem in
a broader problem in
a large spanner in
a universal problem in
a large tree in
a consistent problem in
a serious problem in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com