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The phrase "a large problem due" is not correct and seems incomplete in written English.
It may be intended to express that a significant issue is caused by something or is expected to occur at a certain time.
Example: "There is a large problem due to the lack of resources for the project."
Alternatives: "a significant issue caused by" or "a major problem resulting from".
Exact(1)
Sex-selective abortion remains a large problem due to the low status of women and the preference for male offspring among South-Asian individuals [ 21].
Similar(59)
Misclassification seems to be a large problem in these studies due to imprecise or vague definitions of insufficient milk supply.
It is a large problem.
But this is not a large problem.
(i) "no problem", (ii) "a small problem", (iii) "neither a small nor a large problem", (iv) "a large problem", (v) "a very large problem".
However, a larger problem is that the mass of the Sun would increase the acceleration due to gravity by a factor of about 300000.
While this ungainliness is partly due to Stantz's deliberately numbed voice, it hints at a larger problem.
Now, a larger problem.
It just becomes a larger problem".
There is a larger problem.
Sayre faces a larger problem.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com