Sentence examples for a large pathway from inspiring English sources

Suppose that only a small portion of a large pathway is involved, standard statistical tests would fail.

In fact, the expression/correlation behaviour of a large pathway could be misleading, hiding significant parts of the pathway mostly involved in the biological process under exam.

However, testing all the SNPs in the set may decrease the statistical power, particularly when there is only a portion of the SNPs that have effects on the disease in a large gene or a large pathway.

Limitations of this study include the focus on only two genes in a large pathway, the lack of an independent replication outside of the Mayo Clinic and Duke University datasets, and the lack of functional analyses.

Through extensive experiments involving a large pathway database, we demonstrate that when compared with a state-of-the-art alternative, the CAMPways algorithm provides better alignment results on metabolic networks as far as measures based on same-pathway inclusion and biochemical significance are concerned.

Using the various notations available in SBGN format, these two databases have not only been able to show a large pathway but also been able to show various complex reaction processes such as complex formation, conformational modification of proteins, phosphorylation and compartmentalization of chemical reactions of a signal transduction network.

In fact, the example in Figure 2C discussed previously suggests the value of providing a larger pathway.

Therefore, we focused on the nuclear import and export rates of unphosphorylated STAT5 with the goal to generate rates for the steady state in unstimulated cells that can be set to a fixed value in a larger pathway model.

In addition, our findings that changes in transcription and OR frequency following unilateral naris occlusion are significantly reduced but not eliminated in H2be-KO mice indicate that H2BE plays a key role in modulating activity dependent changes, but is likely part of a larger pathway.

The equations that describe the system in terms of fluxes are (3) X ˙ 1 = v 1 − v 2 X ˙ 2 = v 2 − v 3. X ˙ 3 = v 3 − v 4 The system could be part of a larger pathway system, but for this illustration the context is not relevant.

These genes were chosen as both a part of a larger pathway-based group of genes studied in our laboratory in this and other types of human cancers and because they are generally considered among the most important cell cycle control TSGs known to be inactivated via methylation in cancer (38– 40).