The phrase "a large modification of" is correct and usable in written English.
It can be used when discussing significant changes or alterations made to something, such as a document, design, or process.
Example: "The project required a large modification of the original plan to meet the new requirements."
Alternatives: "a significant change to" or "a major alteration of".
From the results for the given numerical example, it is shown that even in the cases with a large modification of structural parameters the proposed iterative procedure can provide exact predictions of the modified modal parameters after only a few iterations, and the high order approximation approach can give excellent estimates.
This was well demonstrated by the model, where the large CaMK facilitation could be expected to produce a large modification of E-C coupling, but in silico the effect turned out to be rather small.
Consistently the proteomic analysis shed light on large modification of enzymes involved in the transport and catabolism of metabolites necessary for energy production.
Adaptations to a new environment, such as a polluted one, often involve large modifications of the existing phenotypes.
Adaptation to a new environment, such as a polluted one, often involves large modifications of the previous phenotype(s) and changes in gene expression and regulation during critical developmental stages may explain these phenotypic changes.
The notion of hypersensitivity is illustrated: a weak geometrical modification, a defect in connexion angle, can under certain conditions lead to large modifications of the vibrational behaviour.
Both multiple mutants display large modifications of stability and activity arising from synergic effects in comparison with single mutations.
The methods in [7, 8, 9, 10, 11, 12, 13, 14] need large modifications of the radomes or antennas and lead to high cost.
The largest modification of the approach apart from the changed network representation is to toggle edge membership rather than node membership in candidate subnetworks, as described below.
In order to optimise the activity of the lead compound Cmpd (S −130 (3), we started by exploring larger modifications of the aromatic part of the molecule (selected examples are included in Table 1).
