The phrase "a large modification" is correct and usable in written English.
It can be used when referring to a significant change or alteration in a particular context, such as in technical, academic, or general discussions.
Example: "The software update included a large modification to the user interface, improving overall usability."
Alternatives: "a significant change" or "a major alteration."
Subsonic shell waves are demonstrated to interact strongly with supersonic shell waves to cause a large modification in the radiated intensity distributions near the shell surface.
Carbonate production stayed active through the Ladinian magmatic phase, but the onset of volcanism was associated with a large modification in the platform carbonate facies, which became dominated by automicrites.
However, as previous results have shown that the use of Ca-salts of flaxseed oil did not allow a large modification in milk fat composition, the cheapest flaxseed product will be recommended to incorporate in the dairy cow diet.
From the results for the given numerical example, it is shown that even in the cases with a large modification of structural parameters the proposed iterative procedure can provide exact predictions of the modified modal parameters after only a few iterations, and the high order approximation approach can give excellent estimates.
DIF was considered for any item with a large modification index (>.30).
This was well demonstrated by the model, where the large CaMK facilitation could be expected to produce a large modification of E-C coupling, but in silico the effect turned out to be rather small.
When the same number of fragment ions is distributed over a larger m/ z range for the same peptide sequence carrying a larger modification, the likelihood that the scoring algorithm picks noise peaks would increase (see also the discussion on the b/y-ion free window above), which would in turn lead to lower scores.
The results show that the automated procedure can accurately produce pulse responses corresponding to the mode excitations and the flutter characteristics of AGARD 445.6 wing in a very large modification range.
The neighborhoods are typically ordered in a nested way, i.e. the first (last) neighborhoods result in a comparatively small (large) modification respectively.
Although structural changes in [Mn6]2+ as a cause of the large modification in the relaxation dynamics certainly cannot be ruled out, it seems likely that the role of the [ReIVCl6]2− anion is non-innocent.
