The phrase "a large margin in" is correct and usable in written English.
It can be used when discussing differences in scores, results, or measurements, indicating a significant gap between two values.
Example: "The team won the game with a large margin in points, securing their place in the playoffs."
Alternatives: "a significant gap in" or "a wide difference in".
Mr. McConnell is leading his challenger by a large margin in internal polls.
Specifically, discriminative NMF outperforms standard methods by a large margin in improving signal-to-noise ratio for reconstructing signals.
Despite having surpassed analysts' expectations -- by a large margin in the cases of Citigroup and Merrill Lynch -- the companies got only a slight boost from investors.
They succeeded in making the gun-background-check issue a major topic of debate in the elections that year, but McDonnell won by a large margin in November.
Rim Jong-sim won by a large margin in the women's 75kg weightlifting on Friday, one weight category higher than her triumph at London 2012.
You have across-the-board systematic, willful noncompliance with straightforward labor law by a large margin in a way that's very destructive to workers".
Beyond that, there are six states that while decided by a larger margin in 2000, were described by analysts and aides to Mr. Bush and Mr. Kerry as potentially in play this year: Arizona and West Virginia, followed by Delaware, Colorado, Louisiana and New Jersey.
It is designed to be a little skeptical that, for instance, Mr. Obama is actually leading by a larger margin in Ohio (by about three points in the polls) than in the national numbers (where he leads by about two points).
Recent polls suggest that Mr. Lazio is leading upstate by a margin of about 10 percentage points, but political analysts say he needs a larger margin in the region to overcome the overwhelming support that Mrs. Clinton is expected to receive in New York City.
Mr. Obama won Colorado by a larger margin in 2008 — by 8.9 percentage points, against 6.3 in Virginia — but that isn't all that large a difference; small enough that some of these differences could reverse their order on the electoral map.
