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The phrase "a large margin and" is correct and usable in written English.
It can be used when discussing differences or gaps in various contexts, such as competition, performance, or measurements.
Example: "The team won the game by a large margin and secured their place in the finals."
Alternatives: "a significant gap and" or "a wide difference and".
Exact(32)
She lost by a large margin and is remembered largely for having declared that she "didn't really need the job".
He won the election by a large margin, and the Democrats won majorities in both branches of Congress.
In 1974, in his race for the Senate, he defeated an incumbent Republican, Marlow Cook, by a large margin, and he was never threatened in three re-elections.
The ABC is the most trusted media organisation in the country by a large margin, and is one of the nation's most trusted institutions.
But he still won by a large margin and served in Congress before he was stripped of his seat, convicted and sent to prison.
The Turkish prime minister, Recep Tayyip Erdogan, was re-elected on Sunday by a large margin, and he now faces a major domestic challenge.
Similar(28)
It could simply be that investors hoped the company would beat expectations by a larger margin, and impress with its forward guidance.
The only real choices are to go low and hope to build up revenue through volume, or to go high and sacrifice sales in favour of a larger margin and increased turnover.
Apple CEO Tim Cook said in the press release accompanying today's announcement that sell-through records with this generation of iPhone were exceeded "by a larger margin" and that the company could have sold "many more iPhones with greater supply".
Costa Mesa won the Battle for the Bell because it won its game by a larger margin and Estancia's victory gave the Eagles second place in league.
More recently, US centers have begun exploring three-dimensional external beam techniques as a noninvasive option, despite the requirements for a larger margin and a subsequent higher integral dose to surrounding tissues [ 10].
More suggestions(16)
a large range and
a considerable margin and
a substantial margin and
a broad margin and
a significant margin and
a wide margin and
a large profit and
a large proportion and
a large majority and
a large variance and
a massive margin and
a therapeutic margin and
a large plate and
a solid margin and
a large restaurant and
a clear margin and
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com