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The trial has no planned interim efficacy looks or relevant stopping rules because the primary outcome is only available at birth, with a large lag between recruitment/randomization and availability of the primary outcome (at least 12 mo), and a number of important secondary outcomes are assessed at 6 mo of age.
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In addition, translation of research findings still suffers a large lag time between initially capturing data in the field and subsequently gaining access to relevant public health information.
A large lag results in better performance but at the same time limits the estimation range.
That is to say, there was a large lag-effect.
Then there is a large time lag between drilling wells and production.
In order to avoid a large time lag between the initial population-based postal survey questionnaire (Q1) and the subsequent clinical examination (Q2 and CE), the Q1 questionnaire are sent in three dispatches to allow time for the clinical examinations in the interim.
Furthermore, among women, after excluding those with a large time-lag between blood sampling and CPET, significant positive associations between continuous irisin levels and peakVO2 or oxygen pulse became apparent in a fully adjusted model.
The large lag time between local deglaciation and failure suggests that the events were not directly triggered by deglaciation.
A further complicating factors concerns the large time lag between childhood and adulthood; the longer the period between determinant and outcome, the larger the number of possible intermediate pathways.
Because the number of intervals decreases with an increasing lag time, this method has very high error for large lag time values.
More quantitative statements would require analyses of the type described by van Dijk et al.27, but focusing on a later period to take account of the large time lag between ultraviolet exposure and the development of skin cancer.
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CEO of Professional Science Editing for Scientists @ prosciediting.com