The phrase "a large issue of" is correct and usable in written English.
It can be used when discussing a significant problem or topic that is being addressed or considered.
Example: "The report highlighted a large issue of environmental degradation that needs immediate attention."
Alternatives: "a significant problem of" or "a major concern regarding".
Mr. Khodorkovsky announced a "reorganization" of Yukos, and he prepared a large issue of the new shares to water down Mr. Dart's stakes.
Mr. Khodorkovsky announced a "reorganization" of Yukos that shifted assets to offshore companies, and he prepared a large issue of new shares to water down Mr. Dart's stake.
During the 17th and 18th centuries there was a large issue of enormous plates of copper, stamped with their full value in silver money as a countermark.
Another purpose for a large issue of silver coins, regardless of denomination, was to retire the Fractional currency—low-value paper money or "shinplasters".
The flying eagle design was adopted for a large issue of experimental patterns given to government officials and others in 1856; that coin was then used for the regular issue from 1857.
"In general too with peacekeeping missions, there has been a larger issue of not having enough women in uniform.
And, and I think that racial profiling is part of a larger issue of how we deal with race in America.
They don't want to be seen as having built it up into something bigger or trying to make a fuss or make it a larger issue of justice.
Top advisers said they would seek to make the Republican candidates' statements into a larger issue of character, one that they hoped would reinforce Mr. Romney's image among many voters as a shape-shifting politician who has reversed position on abortion and gay rights, gun control and other issues — as his Republican rivals complained throughout their long nomination battle.
Thanks to its CEO's remarks, Microsoft suddenly has become the poster child for what critics see as a larger issue of disparate pay in the technology sector and beyond.
Yet the trend these studies capture speaks to a larger issue of incarceration in the United States.
