The phrase "a large issue in" is correct and usable in written English.
It can be used when discussing significant problems or topics within a specific context or field.
Example: "Climate change is a large issue in environmental science that requires immediate attention."
Alternatives: "a major concern in" or "a significant problem in".
(A mistake, Ms. Berry later conceded. That's for sure, since the report would have been a large issue in the Senate campaign if Mr. Giuliani hadn't dropped out).
It's important we addressed that – it's become such a large issue in our country and you can't be casual about it.
It's not surprising that the health care legislation that the late Senator Edward M. Kennedy spent years fighting for has become a large issue in the campaign for his Senate seat.
Brugnaro, who says he is neither "left or right" in his political leanings and does not formally represent any party, sees the debate as part of a large issue in what he deems to be a "culture of no" that can dominate important decisions in Italy.
Community service was required of staff members, and Mr. Corzine required it of himself, volunteering at soup kitchens, shore cleanups, winter coat drives — not grand scale, perhaps, but things that always kept the "human face" of a large issue in clear focus.
This was a large issue in the area during the whole of the 1980s.
It's indicative of a larger issue in California.
Yet the debate over Prove It, familiar in cardiology circles, offers insight into a larger issue in pharmaceutical research: the way that marketing concerns sometimes shape scientific studies.
This gets to a larger issue in the language, and to the case of "proprietary eponyms," words that move from corporate brands to general nouns (and even verbs) thanks to their ubiquity.
Applying to nine or more schools is indicative of a larger issue in which students apply to as many schools as they feel some kind of connection to (or that Mom and Dad feel a connection to), and deal with that small detail called "fit" later on.
Buildings with a lack of parking for residents often represent a larger issue in the community.
