The phrase "a large insertion of" is correct and usable in written English.
It can be used when referring to a significant addition or inclusion of something, often in a technical or academic context.
Example: "The study revealed a large insertion of new data that changed the overall conclusions."
Alternatives: "a significant addition of" or "a substantial inclusion of".
PI3-SH3 is peculiar due to a large insertion of 15 amino acid residues in the n-Src loop when compared with more canonical members of the family.
Around the 93E18.3 and 93E18.5 Cgenesenes, located in the flanking region of the genetic interval of S1A, sequence comparisons showed a large insertion of 13,123 bp of sequence in CG14 relative to Nipponbare (Figure 3, box A).
Six sequences contained indels: Ascolaimus, Bolbolaimus and Microlaimus sequences showed a deletion of one amino acid at position 19, the Eleutherolaimus sequence showed two insertions at positions 87 and 88 and Praeacanthonchus/Paracanthonchus sequences showed a large insertion of nine amino acids compared to all other sequences in the alignment.
We also tried one donor carrying a large insertion, of a mini-white gene.
R45 has a large insertion of 570 residues, comprising mostly His, Lys, Asn, Ser and Asp residues, relative to the other members of the FIKK family.
The size of Ce5 is strongly conserved (45 50 kb), and we have found only one strain (LW1509) that contains a large insertion of DNA in this region.
It could be best reconciled with the presence of a larger insertion of DNA of unknown origin.
Previously, we showed that the gains of trans-spliced group II introns by petD and psaC and of a large insertion by rps4 distinguish the members of the OCC clade from those belonging to the CS clade [ 15].
One Leishmania protein (LmjF34.0870) has a large insertion in the middle of its CCCH motif, while the CCCH motifs of Tb and Tc are intact.
These regions could correspond to a large insertion in the genome of S. chlorophenolicum or a large deletion from the genome of S. japonicum.
For example, a large insertion affecting the expression of BMP12 has been shown to be the causative mutation associated with the naked neck trait (Mou et al. 2011).
