The phrase "a large increase of" is correct and usable in written English.
It can be used when discussing a significant rise in quantity, amount, or degree of something.
Example: "There has been a large increase of interest in renewable energy sources over the past decade."
Alternatives: "a significant rise in" or "a substantial growth of".
However, this search could become largely samples-, time- and money-consuming, leading to a large increase of the requested RT QPCR assays to fulfil all the criteria needed to determine the best HKG or set of HKGs.
This metastable austenite then progressively transforms during straining, bringing about a large increase of the work hardening rate.
In the last two years, I have seen a large increase of noninstructional requirements and the time it takes to complete them.
During this process, the activated divertor will cause a large increase of radiation in the ITER building.
Elongation of this domain during the onset of crack growth causes a large increase of the fracture toughness.
XPS, EDX and ICP-OES measurements showed a large increase of fluorine content inside the residual powder.
The results show a large increase of the conformational energy of the adsorbed sample as compared to the bulk.
Another real and contentious issue has been a large increase of pregnant mainlanders coming to Hong Kong to have their babies in the city's world-class maternity hospitals.
This particular step will offer a large increase of AuNP size and surface area due to the change of nanoparticles shape.
High heat flux PFCs based on copper alloy heat sink structures have been developed in order to enable a large increase of power extraction capacity.
A large increase of grasses Calamagrostis epigejos, Bromus inermis and Brachypodium pinnatum has often been observed in many regions enriched by higher nitrogen (N) wet deposition inputs.
