The phrase "a large increase in expression of" is correct and usable in written English.
It can be used in contexts discussing biological, scientific, or data-related topics where you want to indicate a significant rise in the level of expression of a particular gene, protein, or other measurable entity.
Example: "The study revealed a large increase in expression of the target gene after treatment with the new drug."
Alternatives: "a significant rise in expression of" or "a substantial increase in expression of".
SKF 81297 induced a large increase in expression of Zif268 and Arc/Arg3.1, specifically in the granule cell layer of the DG (Fig. 9A); Zif268 expression increased at 30 min, peaked at 60 min and returned to basal levels 360 min after SKF 81297 administration (Fig. 9B).
M. tuberculosis infection of epithelial cells results in increased expression of BCL2 and pRb, decreased expression of BAX and BAD, and no change in p53 expression despite a large increase in expression of p53 in infected macrophages.
The large increase in expression of Ddit4 suggests inhibition of the Frap1 (TOR) pathway by CR.
In this pathway, we found a large increase in the expression of the gene encoding tyrosine aminotransferase [TAT; EC:2.6.1.5].
Contrary to this, Klein et al. found a large increase in SUC2 expression in a Δmig1 strain and further increase by additional disruption of MIG2 [ 37].
The 16-fold increase in Slc11a1 expression would be expected to be associated with a large increase in uptake of molecular iron.
Furthermore, BMSCs seeded on the Yarn-CH scaffold demonstrated a large increase in the glycosaminoglycan content and expression of collagen type II following a 21-day culture.
Expression of PR as an intramolecular multimer resulted in a large increase in PR activity in comparison with the level obtained with the expression of PR as a monomer.
Spinal nerve ligation altered the expression of nicotinic acetylcholine receptor subunits ipsilaterally, with a large increase in the modulatory α5 subunit.
They also found a large increase in small adipocyte recruitment in the retroperitoneal fat pad, as well as a suppression of leptin expression in mature adipocytes.
This study showed a larger increase in OX1R expression in the pancreatic islets of rats with long-term DM compared to those with short-term diabetes.
