The phrase "a large increase in bone" is correct and usable in written English.
It can be used in contexts related to medical, biological, or anatomical discussions, particularly when describing changes in bone density or mass.
Example: "The X-ray results indicated a large increase in bone density, suggesting significant improvement in the patient's condition."
Alternatives: "a significant rise in bone" or "a substantial growth in bone".
Soft tissue grafts lead to a larger increase in bone tunnel diameter in comparison to bone-tendon-bone grafts [ 2, 3].
Diurnal variation is a well-established and important parameter of bone turnover, with bone resorption marker levels decreasing by approximately 50% after food intake compared with those of fasting individuals, and an equally large increase in bone resorption marker levels occurring during the night [ 75- 77].
Polarized light microscopy revealed disorganized bone collagen architecture as has been previously observed, as well as a large increase in the areal porosity of the bone compared to typical values for healthy cortical bone, with large (several hundred micron sized), asymmetrical pores.
An overall large increase in bone formation occurred for all groups from 3 to 6 weeks.
This explosion of data has led to a large increase in knowledge and the subsequent introduction of new bone-targeted therapies in daily practice.
Thus, MSC ERK KO mice show severe limb deformity associated with lack of cortical bone, ectopic cartilage formation and a large increase in the number of hypertrophic chondrocytes.
Early screening allows us to establish your bone density and gives us the opportunity to suggest lifestyle changes that can improve bone strength.' Bone specialists in Oxfordshire became alarmed when they noticed a large increase in women contacting their GPs after a screening from MSS which had just targeted their region.
Similarly, chondrocytic differentiation was highly disorganized in long bones and bones of hands and feet, and was associated with a large increase in the number of hypertrophic chondrocytes.
Leukemia, a cancer of the blood-forming tissues characterized by a large increase in the numbers of white blood cells (leukocytes) in the circulation or bone marrow.
