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The phrase "a large impact in" is correct and usable in written English.
It can be used when discussing the significant effect or influence something has in a particular area or context.
Example: "The new policy is expected to have a large impact in improving employee productivity."
Alternatives: "a significant effect on" or "a major influence in".
Exact(33)
The Indian vote could also have a large impact in Arizona, Nevada and New Mexico.
His work had a large impact in human-factors engineering, or ergonomics, which is partly concerned with the perceived affordances in products designed for human use.
The expansion of Medicaid would have a large impact in relatively poor states like Arkansas, where current eligibility criteria for adults are strict and chronic conditions like diabetes and obesity are widespread.
The program, which placed 130,000 foreign students in all sorts of jobs across the country this year, has a large impact in shaping the country's image for young generations overseas.
It was in fourth place in the 2010 survey and finished first in 2009, a ranking that was attributed at the time to optimism surrounding the dawn of the Obama presidency "Global political and financial events had a large impact" in the 2012 survey, said Daniel Rosentreter, chief strategic officer for North America at FutureBrand.
For the other site to be unveiled on Friday an 8,500-square-foot 8,500-square-foot 8,500-square-footks away by the Boardwalk, Mr. Fung asked the artist John Roloff to make a large importion a much smaller space.
Similar(27)
It is possible that the three-bucket rule would have a larger impact in Europe.
Spending the same $100,000 in Vermont might make a larger impact in the popular vote — perhaps 2,000 votes per $100,000 of spending.
Thus, policies geared toward increasing the size of remittances, rather than the incidence, will have a larger impact in the fight against child labor.
Overall, rainfall had a larger impact in vegetated areas at the degraded site implying that larger carbon losses can be expected as a result of land degradation.
It is hypothesized that flammable gas addition has a larger impact in the isolated regime, as the gas acts to bridge individual diffusion flames during flame propagation and explosion.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com