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The phrase "a large hit and" is not complete and lacks context, making it difficult to determine its correctness in written English.
It could be used in contexts discussing the impact or success of something, but it needs to be part of a complete sentence for clarity.
Example: "The movie was a large hit and received numerous awards for its outstanding performances."
Alternatives: "a significant success" or "a major hit."
Exact(1)
With 14 arrested, their numbers had taken a large hit and I was unsure if they'd even be able to block the site again, let alone put a complete stop to the exploratory drilling.
Similar(59)
Montreal-based aerospace and transportation company, Bombardier, suffered a large hit to its reputation this year and saw its RepTrak Pulse rating fall from 66.2 (still not great) to a dismal 56.7.
In either BLASTP search, the same effective database size (computed based on target consisting of UniProtKB sequences), e-value threshold (10) and a large hit list size (10 million) are used as parameters.
It was not in contiguous memory, and the hopping around took a large hit.
Iran will take a large hit.
The parties, which were the chief beneficiaries of soft money, may take a large hit.
In London and New York, the stage version of Dracula had been a large hit in 1927.
When the cue is being pushed forward for a large hit, shift your body weight behind it too.
A larger head will provide more power and a larger hitting area and sweet spot than a smaller one.
If they lose, the community itself will take a larger hit in terms of the assessment of its effectiveness".
But survey measures of business activity have taken large hits and a significant portion of firms say they will invest less as a result of the Brexit vote.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com