As both pain and analgesic responses have large hereditary components [21], a genetic approach in mechanistic pain studies may both lead to an increased understanding of the pathogenesis of chronic pain as well as suggest pharmacogenomic options for improving treatment.
Such genes may account for the hitherto mysterious observation that many illnesses have a far larger hereditary component than can be accounted for by variations in protein-coding genes.
There's also a large genetic component in there.
Twin studies also argue for a large genetic component.
Clinical manifestations in a large hereditary hemorrhagic telangiectasia (HHT) type 2 kindred.
Thus, familial HL is an example of a disease in which a hereditary component is apparent but little is known about its molecular background.
The general belief is that idiopathic scoliosis is a multifactorial condition, with a hereditary component (Grauers et al. 2012).
OA has been widely considered to be a polygenic disease, having an important hereditary component [ 25].
Between 20 to 40% of retinoblastoma, an embryonic tumor, may have a hereditary component [ 33].
In the class of Anxiety Disorders, OCD is a pathology that shows an hereditary component.
