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The phrase "a large fraction are" is correct and usable in written English.
It can be used when discussing a significant portion of a group or population in relation to a specific characteristic or condition.
Example: "In the survey, a large fraction are in favor of implementing the new policy."
Alternatives: "a significant portion are" or "a considerable number are".
Exact(1)
The number of California applicants by race and year can be found at http://statfinder.ucop.edu While not all of the minorities applying, enrolling, or graduating from UC campuses are from California's public high schools, a large fraction are and we use this benchmark to account for the trends in the numbers of minorities at risk to go to college.
Similar(59)
A large fraction is thus released at the inner core front.
Once there, a large fraction was carried internally away from the dox-exporting pumps at cell membrane and toward the nucleus.
In S. cerevisiae, FAs are degraded by β-oxidation and a large fraction is utilized to synthesize steryl esters (SEs) and triacylglycerols (TAGs), which are not essential for the cell.
Most CX3CR1− GC B cells expressed CD38, a large fraction was CD77+, a half was CD27+, one third was CD44, whereas CD23, sIgM, sIgD, sIgG and Bcl-2 were detected in lower proportions of cells (Fig. 4A).
Among 1 kbp simulated homozygous insertions, a large fraction were found and correctly assembled (recall values between 65 98.4%, precision >97%).
Perhaps most important in terms of detection is the fact that most additional cancers detected using tomosynthesis tend to be invasive, with a large fraction being node-negative.
Although B. subtilis was able to produce and secrete this protein in high amounts into the growth medium, a large fraction was not correctly folded and quickly degraded.
Although some members of this family are predicted to function as active RNases, a large fraction is likely to be inactive on account of the loss of the conserved motif (Table 1).
The WAF contained an estimated 2.8 mg/L total PAH (initial) but has the disadvantage of a high proportion of other oil components such as alkanes because a large fraction is present in particulate or colloidal form.
Normally, genistein is freely absorbed from the intestine and a large fraction is converted to 7 β-O-glucuronide as it crosses the brush border and ultimately enters the portal vein [ 24].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com