It is apparent that, despite a large fold change, the shapes of the peaks are very similar in the two cell lines.
As the symbionts reside solely in the gastrodermal tissue of the host, a larger fold change of expression in the tissues which harbor symbionts could be hidden by non-differential expression of the same genes in non-symbiotic tissue.
However, these NK cells had a more marked responsiveness as demonstrated by a larger fold increase in cytotoxic function (upregulation of CD107a) when a stronger NK-cell stimulus was employed (Fig. 4).
However, in the GABAA receptor, a large 400-fold loss-of-function was observed, similar to that seen here in the GluClβ receptor.
The binding of HU to a DNA four way junction is several orders of magnitude higher in comparison to binding to linear DNA even under high salt conditions [21] and is not inhibited by a large (100 fold) excess of competitor linear DNA.
Thus, for microarray analyses involving complex tissues such as brain, low fold changes in gene expression may indicate large fold changes in a subset of cells or cells in a particular region of the tissue and should not be overlooked.
Thus, for gene expression analyses involving complex tissues such as brain, low fold changes in gene expression may indicate large fold changes in a subset of cells or cells in a particular region of the tissue and should not be overlooked.
In the presence of a large excess (200 fold) of cold competitor, the extended paired domain PD 2a) did not bind to CD19-2, thighigh affinity binding site for the shorter eyeless paired domain [50], (Fig. 5B, compare lanes 3 and 7).
These sex biased genes had a large range of fold differences between the sexes, with most having only modest effects of 1.2 to 1.5 fold, but also included 233 transcripts with 2 to 3-fold effects, 40 transcripts with 3 to 10-fold effects, and 10 transcripts with >10-fold effects (Table 6).
Relative to the IFN-β treatment group, the combined treatment (IFN-β + APAP) resulted in a large increase (3 fold) of the number of genes with FDR p-values<0.05 at both 1.5 h and 4 h time points, suggesting that APAP significantly alters the gene expression pattern induced by interferon treatment (Table 1).
