The phrase "a large estimate" is correct and usable in written English.
It can be used when referring to an estimate that is significantly high in value or quantity.
Example: "The contractor provided a large estimate for the renovation project, which surprised the homeowners."
Alternatives: "a significant estimate" or "a high estimate".
While I do not expect such a large estimate reduction for America's shale gas resource base, substantial reductions are warranted given the production history of shale fields and our increased understanding of their potential.
If the value of T s is too small, it may result in a large estimate error of ( hat {u_{i}^{k}}(t)), while too large, it may reduce the sensitivity to queue variations.
In particular, the small number of never smoker libraries results in a large estimate of the "preferentially" expressed never smoker tags.
OsSRP-LLS (Os11g13530) was expressed at low levels (values <500) except that expression was higher in Stage 4 of grain development (although at a value associated with a large estimate of error).
First, a large j m (or r m) estimate in a previous iteration often results in a large estimate in the current iteration, and, as a consequence, the choice of initial values of j and r influences heavily the point at which they converge.
Standard Cox models that do not incorporate adjustment for competing risk consistently provided a larger estimate of effect.
We found that incorporating genomic imprinting in GWAS produced a larger estimate of phenotypic variance accounted for by significant markers.
Results were not affected by outcome reported, or condition treated, but smaller trials yielded a larger estimate of efficacy.
A larger estimate of the duration of carriage (45 days) was found by Auranen et al. [ 13] for subjects older than 2 years old.
Because inadequate sequence generation in randomisation studies also tends to yield a larger estimate of treatment effects, this is another source of potential bias.
