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The phrase "a large effect on" is correct and usable in written English.
It can be used when discussing the impact or influence that something has on another thing.
Example: "The new policy had a large effect on employee productivity and morale."
Alternatives: "a significant impact on" or "a major influence on".
Exact(60)
Two factors in particular had a large effect on revenues.
Coffee has a large effect on my mood.
The actions of a subject's contacts can have a large effect on the subject himself.
The software used on a computer can have a large effect on the speed.
This factor has a large effect on Europe, Asia and the Arctic.
The data suggest that gender has a large effect on hypoxic breathing response.
Each assessment also has a large effect on the next within the same subject area.
Taking on the diet of the adopted country often has a large effect on physical traits.
Because the population is relatively small, slight increases in cases can have a large effect on statistics.
The social credit system, which was introduced in 2014, has had a large effect on life in the country.
Moreover, changing the nature of nitrogen protecting group in substrate has a large effect on the transformation.
More suggestions(16)
a wide effect on
a substantial effect on
a massive effect on
a considerable effect on
a broad effect on
a wide ranging effect on
a large scale effect on
a big effect on
a great effect on
a large focus on
a significant effect on
a broader effect on
a huge effect on
a major effect on
a large impact on
a pronounced effect on
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com