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The phrase "a large drop in" is correct and usable in written English.
It can be used when discussing a significant decrease in a particular quantity or measurement, such as prices, performance, or statistics.
Example: "There was a large drop in sales during the last quarter, which raised concerns among the management team."
Alternatives: "a significant decline in" or "a substantial decrease in".
Exact(60)
Microsoft reports a large drop in e-mail spam.
The outbreak caused six million animals to be slaughtered and a large drop in tourism.
The second significant assumption is that this contribution would have produced a large drop in unemployment.
A large drop in formerly joyful Spain ensured a modest overall decline for the rich.
As in 1931 and 2008, a grave financial crisis may cause a large drop in output.
A large drop in methanol concentration methanol is measured at the inlet section of cell.
In all cases, a change in specificity was accompanied by a large drop in enzymatic efficiency.
After three years, costs for hospital stays dropped by $1.6 million, accompanied by a large drop in readmissions.
Property Partner said a large drop in the number of empty homes across England from 2006 stalled in 2015.
But when they are oriented in opposite directions, both types of electrons encounter resistance, causing a large drop in current.
A measure of manufacturing activity in New York State jumped in May, reversing a large drop in April.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com