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The phrase "a large disruption of" is correct and usable in written English.
It can be used when describing a significant interruption or disturbance in a process, system, or situation.
Example: "The storm caused a large disruption of transportation services across the region."
Alternatives: "a significant interruption of" or "a major disturbance of".
Exact(2)
The goal of the reactive control loop is to detect the occurrence of a large disruption of the system.
It has been clear for some time that bradykinin and IL-1β, with other substances, are involved in a cascade of events that leads to a large disruption of the blood brain barrier [42,43], which is the basis of vasogenic edema.
Similar(58)
Considering the second manipulation (the effect of mask contrast on thresholds): Because, unlike with spatial frequency or orientation, the neuronal representation of contrast is not narrowly tuned, there is an open question: Do masks at the same or different contrast produce a larger disruption of performance when they are delivered during the memory interval?
Previous reports indicate that younger patients may suffer higher levels of distress (Wenzel et al., 1999; Carlson and Bultz, 2002), theorised to be due to a larger disruption of social and familial roles at earlier developmental stages, such as raising small children and establishing careers.
Such an intervention may allow manipulation in the mammalian gut without large disruption of the microbiota.
The wave of displacement is just the start of a far larger disruption of the area's population anticipated as fighting continues and Iraqi forces prepare to retake Mosul, the second largest city in Iraq that fell to ISIL in June 2014.
Plagued by politics No easy fix Waste not, want not Doing more with less Our daily bread Not just calories A prospect of plenty Sources & acknowledgmentsReprintsIt would be a huge relief if those 9 billion could be fed without large disruptions of supplies or price spikes.
However, unlike with spatial frequency or orientation, the neuronal representation of contrast is not narrowly tuned, so a question remains open: What kinds of masks lead to larger disruption of performance when they are delivered during the memory interval masks that are similar (or the same) in contrast, implying feature selectivity, or masks that are different in contrast?
The resulting plume of ash wafted southeast over Europe and triggered the largest disruption of the continent's air traffic since World War II.
AWS is dominating the public cloud market, and it is increasingly clear that this market represents the largest disruption of enterprise computing since the introduction of the personal computer.
Though, landslides are considered as one of the most frequent it causes a large scale disruption of natural resources, economic valuables and human lives.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com