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The phrase "a large difference is" is correct and usable in written English.
It can be used when discussing or comparing two or more items, situations, or concepts that exhibit a significant disparity.
Example: "When analyzing the two studies, it became clear that a large difference is evident in their methodologies."
Alternatives: "a significant difference is" or "a considerable difference is".
Exact(10)
A large difference is observed in the cumulative drop surface area and the effective interfacial area on account of the large degree of CO2 absorption taking place during the process of atomization and the large number of internally stagnant drops.
Due to the March quarter being the first full quarter of any meaningful Model 3 production having a large difference is not surprising.
A large difference is also recognized in the phase value of the TM mode at Site 8 for frequencies <200 Hz.
If the instrument response is characterized by f = 0.9 Hz and h = 0.6, the difference from the standard instrument response is not very large, whereas a large difference is recognized for the case of f = 0.5 Hz and h = 0.3.
Interestingly, Jurkat have nearly the same ED50 for Pr uptake as HeLa, but a large difference is seen in cell survival.
Peptides encompassing residues 758 774 and 815 830 in the HSD show small changes in ΔD%, but a large difference is detected for residues 775 783.
Similar(50)
Also, with respect to prevalence and degree of colonization, a large difference was present between soil-grown plants and axenically grown plants.
Such a large difference was due to the stacking of normal/inverse-transient creep in the creep-fatigue test.
A large difference was found in the power of detecting a specific subpopulation showing a clearance decrease of 30% or 50%.
A large difference was observed in cognitive flexibility with FEM patients performing worse than HCs in TMT-B (p = .004), even after family-wise adjustment (i.e. α/5), with a medium effect size (r = .37).37
Concerning parents' working status, a large difference was also found between the mothers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com