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The phrase "a large difference in the amount" is correct and usable in written English.
It can be used when discussing a significant disparity or variation in quantities or measurements between two or more items or groups.
Example: "There is a large difference in the amount of rainfall this year compared to last year."
Alternatives: "a significant variation in the quantity" or "a considerable disparity in the amount".
Exact(4)
This was evidenced by a large difference in the amount of interior forest area share, with China having 48% interior forest versus the 66% for the USA.
Although these differences appear to be numerically small, they actually represent a large difference in the amount of energy released in the earthquake because earthquake magnitude scales are logarithmic.
Our results show that there was a large difference in the amount of cell death (TUNEL staining) between either LVCN- or Avastin-treated groups and the control.
Your credit score is greatly improved if you have a large difference in the amount of credit given to you versus how much of that credit you have actually used.
Similar(56)
One possible explanation could be the large difference in the amount of deformation accumulated on the segments that tried to cross the basin in 1967 and 1999.
Despite the large difference in the amount of analgesics consumed, each group showed improvement in resting and dynamic pain intensity (p < 0.001) (Table 3).
This may be due to the fact that there was not a large difference in amount of fluid received between the control and interventional arms.
However much of the difference in size between the genomes arises from large differences in the amount of DNA in heterochromatic repeat regions [26].
There were large differences in the amount of intravenous salt and total fluid volume infused during surgery.
To account for large differences in the amount of data recorded from each culture, the mean was taken as a weighted average.
(A″ ) Stable amount of puncta and non-puncta in the pre-pupal wing confirms a large difference in stability between regions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com