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The phrase "a large difference in" is correct and usable in written English.
It can be used when discussing a significant disparity or variation between two or more items, concepts, or groups.
Example: "There is a large difference in the quality of service between the two hotels."
Alternatives: "a significant difference in" or "a considerable difference in".
Exact(60)
It has been reported that there was a large difference in etching rates between different polytypes of SiC [20].
De Bekker-Grob et al. found a large difference in medication prescription between different GP's.
A large difference in spectra width has been observed for different oriented surfaces.
A large difference in the likelihoods indicates that the two extremes evolve differently.
Both signals showed a large difference in the CPU time.
There is, however, a large difference in retention.
A large difference in the hop and ping distributions can be noticed.
But we observed a large difference in such behavior by gender.
There is a large difference in the market capitalizations of the two companies.
SIMD vectorization only makes a large difference in performance for low number of cores.
A large difference in baseline tension between lengthening (loading) and shortening (unloading) was also recorded.
More suggestions(17)
a considerable difference in
a wide difference in
a huge difference in
a substantial difference in
a significant difference in
a massive difference in
a broad difference in
a tremendous difference in
a broader difference in
a large scale difference in
a large spanner in
a large interest in
a large concert in
a large apartment in
a big difference in
a large snake in
a large tree in
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com